Clinimacs plus user manual

The selected stem cells, monocytes, dcs, nk cells, b cells, and t cell subsets allow research in the field of regenerative medicine, adoptive immunotherapy, and graft engineering. The clinimacs instrument from miltenyi biotec is a cgmp immunomagnetic selection system primarily designed for processing larger numbers of cells. Unicare users manual for mental health clinicians service desk 885. Discover maccaferri knowhow through our softwarecamacstars 2000 user manualrev00. Accessgudid clinimacs plus instrument 04049934004636 the clinimacs plus instrument is a softwarecontrolled instrument that processes the hpc, apheresis as part of the clinimacs cd34 reagent system. Clinimacs user manual and in accordance with the study of leong et al. Surmounting the developmental challenges of miltenyis. Pdf automation of cellular therapy product manufacturing. Please be sure to select med user as your role, and enter meduser for the mailbox name. All except one of the study site laboratories had previous training and experience using the clinimacs system before the trial. Clinimacs plus user manual keyword after analyzing the system lists the list of keywords related and the list of websites with related content, in addition you can see which keywords most interested customers on the this website. Magnetic selection or depletion of labelled target cells, for example from leukapheresis, can be performed to isolate a desired cell population or for the specific removal of a given cell. Find the user manual you need for your laundry appliances and more at manualsonline.

The integrated computer controls all components of the instrument and directs the system to perform repeated procedures in a standardised sequence. There is also a pdf version of the users guide available. User manual for the cd34 reagent system for more information. The connell and oreilly families cell manipulation core facility cmcf assists dfhcc members in developing new cellbased therapies for patients with cancer who are enrolled in novel therapeutic clinical research protocols. Confirmatory factor analysis and structural equation modeling. Do not exceed the specified pressure ratings of the pxchange sensor or instrument housing. The key components of the clinimacs plus instrument, as outlined in figure 3, are the integrated microcomputer, the magnetic separation unit, the peristaltic pump and various pinch valves. The company is a provider of products and services that support scientists, clinical researchers, and physicians across basic research, translational research, and clinical applications. Miltenyi biotec is a global provider of products and services that advance biomedical research and cellular therapy. Turbidityxchange sensors are limited to deployments of 500m depth or less. The cell processing unit for fully automated washing, fractionation and cultivation of cells represents an integral component of the clinimacs prodigy.

The clinimacs instrument from miltenyi biotec is a current good manufacturing practice cgmp immunomagnetic selection system primarily designed for processing larger numbers of cells. Plus public software library for ultrasound is an opensource software package for tracked ultrasound image acquisition, calibration, and processing. Compumedics computer, laptop notebook and printer user guides, service, compumedics maintenance manuals and owner instruction guide select your compumedics computer,compumedics laptop notebook or compumedics printer manufacturer model to get user owner manual. The enrichment process was carried out as described in the clinimacs user manual and in accordance with the study of leong et al. Instrument a softwarecontrolled instrument that processes the. Comparative schedules of the cd34 selection process with. At the start of the selection processes, apheresis products were 2044 h old. Three concurrent clinimacs plus and prodigy selection splitruns were performed. If we dont have a listing for the name, please use the search function to see if there is any mention of it on our site.

The clinimacs plus instrument has been developed to allow the automated separation of cells on a clinicalscale level in a closed and sterile system. For and notices refer to page description all clinimacse plus instruments can be upgraded to the latest status of the software available in the respective country. Peter jahn and his webinar on the clinimacs prodigy platform, including features, benefits, and workflow examples. Miltenyi biotec is a global biotechnology company headquartered near cologne in bergisch gladbach, germany. It also supports clinical research studies designed to evaluate the safety and efficacy of these novel treatments. Pdf isolation of purified autologous peripheral blood. Prodigy owners manual 27 prodigy diabetes care, llc 1.

Compumedics manual compumedics user and service guide. The clinimacs cd34 reagent system, consisting of the clinimacsplus. As the flexible diaphragm inflates, it presses against the bottom of the cell processing bag. The second part of the webinar focuses on the customized application.

The aim of our study is to compare the results of tcrcd19 depletion obtained with the clinimacs cm and the prodigy systems pd during the last 3 years in our. Displays live video on a standard tv monitor or lcd monitor with vga connection via the image capture unit, which is controlled from the camera handpiece. Clinimacs user manual for the cd34 reagent system clinical trial see clinical performance below using collect the following data on the leukapheresis product for more information. Clinimacs plus user manual keyword found websites listing. For details on selections with clinimacs plus, please refer to the user handbook. As you read through the operators manual, you will find these symbols. However, if you replace the batteries, you should check the time and date. Characteristics of clinimacs system cd34enriched t cell. It was agreed that procedures described in the clinimacs users manual were to. We anticipate this newly developed closed system expansion approach to be a starting point for the development of enhanced throughput clinical scale treg. Clearly, the suggested modest advantage of clinimacs plus with respect to the. The operators manual contains the directions you need to unpack the analyzer, use it for your daily bayer urinalysis and clinitest immunoassay testing and keep it in good working condition. The company offers solutions buzzword covering techniques of sample. The clinimacs system immunomagnetic cell separation in a.

The actual screens used in the system are reproduced in the manual, with information on fileman protocol, methods of data entry, and special terminology. Following is the correct citation for this document. If your sewing machine, accessory, or ephemera has a name on it, this is the place to start. Results of a split validation comparing cd34 selection of peripheral blood stem cell apheresis product with a. Statistical analysis with latent variables users guide linda k. Clinimacs plus cell manufacturing platform products. Statistical analysis with latent variables users guide. Using a singleuse tubing set, including a separation column, the device automatically applied the cell sample to the separation column, performs multiple washing steps, and elutes. Briefly, platelets are removed by soft spins of the. The key features of the cobe 2991 cell processor are its centrifuge and its flexible diaphragm. The clinimacs plus instrument automates cell separation for clinicalscale enrichment of target cells or depletion of unwanted cells in a closed and sterile system. Plus applications include complete enduser software applications for spatial and temporal calibration fcal and realtime data. Clinimacs plus cell manufacturing platform products miltenyi.

The clinimacs prodigy offers a flexible platform for cell processing applications enabling the magnetic separation of different cell types as well as customized cell processing protocols. Automation of cellular therapy product manufacturing. Instrument manuals technical documents resources miltenyi. Prodigy runs took about 1 h longer than clinimacs plus runs, albeit with markedly less. Clinimacs plus instrument clinimacs plus instrument. Surmounting the developmental challenges of miltenyis prodigy cell separation system an integrated, closedsystem cell processing device. Full system control by means of an integrated microcomputer automatized cell. Overpressure can result in damage to the pxchange sensor and the instru ment. Mop manual of operations and procedures registryspecific mopp manual of policies and procedures administrative mrs modified rankin scale nhlbi national heart, lung, and blood institute nyha new york heart association heart failure classification oc operations committee opc objective performance criteria. All except one of the study site laboratories had previous training and experience using the clinimacs system before the trial started. Guidance during setup and operation by the touchscreen graphic user interface. Three preparations were conducted in the prodigy, one using the cd19 vector and. Easily browse and download data sheets or instrument user manuals. View and download bayer healthcare clinitek atlas service manual online.